Proteomic analysis of polyribosomes identifies splicing factors as potential regulators of translation during mitosis

Aviner R., Hofmann S., Elman T., Shenoy A., Geiger T., Elkon R., Ehrlich M., Elroy-Stein O.
(2017) Nucleic Acids Res. doi: 10.1093/nar/gkx326.

Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in Vanishing White Matter Disease.

Gali R., Sharet R., Herrero M., Atzmon A., Shenoy A., Geiger T., Elroy-Stein O.
(2017) J. Neurochem. doi:10.1111/jnc.14024

Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis.

Aviner R., Shenoy A., Elroy-Stein O., Geiger T.
(2015) PLoS Genet. Oct 6;11(10):e1005554

Proteomics-level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease.

Gat-Viks I., Geiger T., Barbi M., Raini G., Elroy-Stein O.
(2015) J. Neurochem. 134(3), 513-526.

PUNCH-P for global translatome profiling: Methodology, insights and comparison to other techniques.

Aviner R., Geiger T., Elroy-Stein, O.
(2014) Translation1(1), eLocation ID: e27516

Novel Proteomic Approach (PUNCH-P) Reveals Cell Cycle Specific Fluctuations in mRNA Translation.

Aviner R., Geiger T., Elroy-Stein, O.
(2013) Genes Dev. 27,1834-1844

Highlighted in:

Miura, G.: “Pack a PUNCH” (2013) Research Highlights, Nature Chemical Biology,9,601. doi:10.1038/nchembio.1347

Lou, K-J.: “Puromycin-associated nascent chain proteomics (PUNCH-P) for monitoring protein synthesis” (2013) SciBX: 6(35); doi:10.1038/scibx.2013.971 [Science-Buisness eXchange;]

Dicodon monitoring of protein synthesis (DiCoMPS) reveals levels of synthesis of a viral protein in single cells.

Barhoom S., Farrell I., Shai B., Dahari D., Cooperman B.S., Smilansky Z., Elroy-Stein O., Ehrlich, M.
(2013) Nucleic Acids Res. Aug 21, 1-10. doi: 10.1093/nar/gkt686

Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.

Cabilly Y., Barbi M., Geva M., Marom L., Chetrit D., Ehrlich M., Elroy-Stein O.
(2012) PLoS One 7(10):e46715.

Quantitative single cell monitoring of protein synthesis at subcellular resolution using fluorescently labeled tRNA.

Barhoom S., Kaur J., Cooperman B.S., Smorodinsky N.I., Smilansky Z., Ehrlich M., Elroy-Stein O.
(2011) Nuc. Acids Res. 39(19):e129.

Mitotic Modulation of Translation Elongation Factor 1 Leads to Hindered tRNA Delivery to Ribosomes.

Sivan G., Aviner R., Elroy-Stein O.
(2011) J. Biol. Chem. 286, 27927-27935.

Species-specific microRNA roles elucidated following astrocyte activation.

Mor E., Cabilly Y., Goldshmit Y., Zalts H., Modai S., Edry L., Elroy-Stein O., Shomron N.
(2011) Nuc. Acids Res. 39(9), 3710-3723.

Evaluation of the endoplasmic reticulum-stress response in eIF2B-mutated lymphocytes and lymphoblasts from CACH/VWM patients.

Horzinski L., Kantor L., Huyghe A., Schiffmann R., Elroy-Stein O., Boespflug-Tanguy O., Fogli A.
(2010) BMC Neurol. 10:94. doi: 10.1186/1471-2377-10-94.

A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter.

Geva M., Cabilly Y., Assaf Y., Mindroul N., Marom L., Raini G., Pinchasi D., Elroy-Stein O.
(2010) Brain 133, 2448-2461.

Translational control of protein kinase Ceta by two upstream open reading frames.

Raveh-Amit H., Maissel A., Poller J., Marom L., Elroy-Stein O., Shapira M., Livneh E.
(2009) Mol. Cell. Biol. 29, 6140-6148.

Diverse poly(A) binding proteins mediate internal translational initiation by a plant viral IRES.

Marom L., Hen-Avivi S., Pinchasi D., Chekanova J.A., Belostotsky D.A., Elroy-Stein O.
(2009) RNA Biol. 6, 446-454.

A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.

Kantor L., Pinchasi D., Mintz M., Hathout Y., Vanderver A., Elroy-Stein O.
(2008) PLoS One 3(11):e3783.

DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis.

Marash L., Liberman N., Henis-Korenblit S., Sivan G., Reem E., Elroy-Stein O., Kimchi A.
(2008) Mol. Cell. 30, 447-459.

Regulation of mRNA Translation during cellular division. Review.

Sivan G., Elroy-Stein O.
(2008) Cell Cycle 7, 741-744.

Ribosomal slowdown mediates translational arrest during cellular division.

Sivan G., Kedersha N., Elroy-Stein O.
(2007) Mol. Cell. Biol. 27, 6639-6646.

Effect of Ku proteins on IRES-mediated translation.

Silvera D, Koloteva-Levine N., Burma S., Elroy-Stein O.
(2006) Biol. Cell. 98, 353-361.

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients.

Kantor L, Harding H.P., Ron D., Schiffmann R., Kaneski C.R., Kimball S.R., Elroy-Stein O.
(2005) Hum. Genet. 118, 99-106.

Naturally occurring antisense: transcriptional leakage or real overlap?

Dahary D., Elroy-Stein O., Soreq R.
(2005) Genome Res. 15(3), 364-368.

The Apc5 subunit of APC/Cyclosome interacts with PABP and represses IRES-mediated translation.

Koloteva-Levine N., Pinchasi D., Pereman I., Zur A., Brandeis M., Elroy-Stein O.
(2004) Mol. Cell. Biol. 24, 3577-3587.

Interaction of hnRNP-C1/C2 proteins with RNA: analysis using the yeast three-hybrid system.

Koloteva-Levine N., Amichay M., Elroy-Stein O.
(2002) FEBS Letters 523, 73-78.

Transcription Coupled-Translation Control of AML1/RUNX1 is Mediated by Cap- and IRES-dependent Mechanisms.

Pozner A., Negreanu V., Goldenberg D., Le S.-Y., Elroy- Stein O., Levanon D., Groner Y.
(2000) Mol. Cell. Biol. 20, 2297-2307.

PDFG2/c-sis mRNA leader contains a differentiation-induced internal ribosomal entry site

Bernstein J., Sella O, Le S-Y., Elroy-Stein O.
(1997) J. Biol. Chem. 272, 9356-9362.

The translational repression mediated by the PDGF/c-sis mRNA leader is relieved during megakaryocytic differentiation.

Bernstein J., Sheffler I., Elroy-Stein O.
(1995) J. Biol. Chem. 270, 10559-10565.